About dolastatines

July 6, 2002
From: Denis Berlemont

First: thank you for this very exciting Forum. You know of course that dolastatins are oligopeptids from Dolabella auricularia, and they are used in research on various cancers (solid tumours, liver, leukemias, and other). The synthesis of dolastatine is difficult, with a poor water solubility. A hydrosoluble semi-synthetic analog (Cemadotine) has been developed.

Do you know if Dolabella auricularia is still collected for medical research, and if the answer is "yes" where are they collected? Is it possible to grow them by aquaculture, and would collecting them damage the ecosystem?
Thanks
Denis Berlemont M.D.
France

Denis.berlemont@wanadoo.fr

Berlemont, D., 2002 (Jul 6) About dolastatines. [Message in] Sea Slug Forum. Australian Museum, Sydney. Available from http://www.seaslugforum.net/find/7430

Arnaud Parenty in an earlier message mentioned his research and the interesting discoveries that have been made on dolastatins from Dolabella auricularia. He may be able to give you information on where to obtain specimens, and whether anyone is culturing them like Aplysia californica. I see no reason why they couldn't be grown by aquaculture. You can find more background information and references on the Dolabella auricularia Fact Sheet. if you look at earlier messages you will see that this species is collected for food in some parts of the tropical Pacific. However for research projects artifical culture would be the only way to guarantee a reliable supply of animals
Best wishes,
Bill Rudman

Rudman, W.B., 2002 (Jul 6). Comment on About dolastatines by Denis Berlemont. [Message in] Sea Slug Forum. Australian Museum, Sydney. Available from http://www.seaslugforum.net/find/7430

Factsheet

Dolabella auricularia

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